About H-E-B Pharmacy

H-E-B Pharmacy is a trusted health and wellness pharmacy in Frisco, TX, serving local customers with convenient prescription and pharmacy solutions at 4800 Main St, Frisco, TX 75033. Rated 4.4 out of 5 from 29 reviews, this Frisco pharmacy offers delivery, drive-through service, and in-store pick-up for fast, convenient access to medications and everyday health essentials. Customers can enjoy a quick visit with free Wi-Fi, and the location is designed for accessibility with a wheelchair-accessible car park, wheelchair-accessible entrance, and wheelchair-accessible toilet. H-E-B Pharmacy in Frisco, Texas accepts cheques, credit cards, debit cards, and NFC mobile payments, making checkout simple and flexible. For convenient pharmacy services in Frisco, TX, call +1 972-377-2261 to get local prescription support and health and wellness assistance.

Last updated: Jun 09, 2026

Business Hours

Closed · Sunday 10 AM-5 PM
Tuesday 8 AM-8 PM
Wednesday 8 AM-8 PM
Thursday 8 AM-8 PM
Friday 8 AM-8 PM
Saturday 9 AM-6 PM
Sunday 10 AM-5 PM
Monday 8 AM-8 PM

Customer Reviews

4.40
Based on 29 reviews
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Ashley Taylor

This is the best pharmacy I’ve ever used. Staff is extremely friendly and helpful!

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Miranda Miller

Christine is the best! Super fast transfer process very helpful in getting me my meds sent quick!

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Tiffany Waldren

The best pharmacy I have ever used. Hands down. Amazing staff members, amazing customer service, and the best prices.

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Natalie Thonethao

Amazing service by the head pharmacist, Arash. Incredibly knowledgeable and helpful. Great prices. My Rx was ready for pickup before I even started my shopping. I will be moving the rest of my Rx to this pharmacy.

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kcin ayubo

I Love this pharmacy and the staff. Its new years eve, and Walgreens, CVS are all closing for the night and will be closed on new years. Walmart ran out of omicef 250, and yet i need to get it for my son who is running 102 fevers. They were able to get the prescription transferred and filled in less …

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Brett Stacey

7:50pm (they close at 8:00pm) went to CVS in Frisco TX to get a script filled for a sick 6 year old..CVS told me I was too late.. to bad.. ran across the street to HEB.. 7:56pm.. (they also close at 8:00pm) HEB filled the script!!! Pharmacist was awesome! Went the extra mile and really helped out me and my …

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Matt Morris

I have several recurring prescriptions, and over the past few years, I have had to move among a few local pharmacies based on changing customer service levels, prices, wait times, etc. I can honestly say this HEB pharmacy is a breath of fresh air compared to those other local pharmacies. They are SUPER friendly, accommodating, prompt, and affordable (via GoodRx).

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Angela T

You ever don’t want to leave good reviews bc u want to keep the place to yourself so they don’t get busy? This is one of those times, but they deserve recognition. I’ve had awful experiences with nearby Walgreens and cvs, but HEB always comes through. They are punctual, efficient and so helpful. The pharmacist there are amazing and I’ll …

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Trinity Howland

This pharmacy staff is some of the friendliest, easiest pharmacy techs I have ever dealt with. They are so understanding and helpful when it comes to medication shortage. Every other pharmacy in the area was rude and unhelpful, but HEB gave me multiple options to help me get my medication and I appreciate them so much. They are my new …

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Alan Billman

We had an HEB when we lived in San Antonio. We loved it. So glad to have it in the DFW area and expanding northward. The Frisco location is really nice inside. Gas station out front. HEB Texas BBQ inside. A small “home” section with things like rugs, chairs and home decor. It’s a big place, but we’ll spaced. If …

People Also Ask

Where is H-E-B Pharmacy located?
H-E-B Pharmacy is located at 4800 Main St, Frisco, TX 75033, United States, Frisco, TX, United States. You can get directions here.
What is H-E-B Pharmacy rated?
H-E-B Pharmacy has a rating of 4.40 out of 5 stars based on 29 customer reviews.
What are H-E-B Pharmacy's hours?
H-E-B Pharmacy's hours vary by day. Please check the Business Hours section above for the full weekly schedule.
How do I contact H-E-B Pharmacy?
You can reach H-E-B Pharmacy by phone at +1 972-377-2261.
What type of business is H-E-B Pharmacy?
H-E-B Pharmacy is a health & wellness business located in Frisco, TX. <!-- VOILA_REWRITTEN --> H-E-B Pharmacy is a trusted health and wellness pharmacy in Frisco, TX, serving local customers with convenient prescription and pharmacy solutions at 4800 Main St, Frisco, TX …